Adonis IGF 1 LR3 – Research Peptide (RUO)

RUO only. Not for human or veterinary use. No dosing or administration guidance provided.

IGF-1 LR3 (Long Arg3) – Research Grade

Buy IGF-1 LR3 peptide for research — IGF-1 LR3 (Insulin-Like Growth Factor 1 Long Arg3) is a recombinant analogue of IGF-1 engineered for enhanced stability and extended biological activity. With an added 13-amino-acid N-terminal extension and an arginine substitution at position 3, IGF-1 LR3 exhibits reduced binding to IGF-binding proteins (IGFBPs), allowing prolonged interaction with the IGF-1 receptor. This makes it a valuable compound in cell growth, regeneration, and metabolic research.

Learn more about its scientific background and study references in our IGF-1 LR3 Research Blog.

Product Information

• Peptide Name: IGF-1 LR3 (Long Arg3 IGF-1)
• Synonyms: Long Arg3 IGF-1, IGF-1 LR3 peptide
• CAS Number: 946870-92-4
• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Molecular Weight: 9117.5 g/mol
• Sequence: 83 amino acids (modified IGF-1 with Arg substitution at position 3)
• Purity: >98% (HPLC tested)
• Form: Lyophilized powder
• Storage: Store at -20°C. Keep desiccated and protected from light. Reconstitute with sterile water for laboratory use only.

Overview

IGF-1 LR3 peptide interacts with the IGF-1 receptor (IGF-1R), initiating intracellular signaling pathways (PI3K/Akt and MAPK) that regulate cell growth, repair, and metabolism. Because of its extended half-life and decreased affinity for IGFBPs, IGF-1 LR3 remains active longer than native IGF-1, making it a preferred research compound for studies investigating muscle regeneration, tissue repair, and cellular growth mechanisms.

Potential Research Applications

• Muscle regeneration and growth: Studying myoblast differentiation, satellite cell activation, and tissue hypertrophy.
• Cell growth and repair models: Supports cell proliferation and recovery mechanisms in tissue-culture systems.
• Metabolic and endocrine pathway research: Examining insulin-like effects and nutrient metabolism.
• Neuroprotective and longevity studies: Investigating IGF-1’s potential role in neuronal health and aging.

Scientific Background

IGF-1 LR3 has been extensively studied for its impact on anabolic signaling and regeneration. The Long Arg3 modification allows continuous receptor engagement, aiding researchers in evaluating long-term IGF-1R activation. Studies have demonstrated its effects on protein synthesis, recovery, and cellular longevity in various in-vitro and in-vivo models.

Safety and Handling

IGF-1 LR3 is intended for research use only and is not approved for human or veterinary applications. Laboratories must ensure appropriate handling under sterile conditions. Follow all institutional biosafety and storage guidelines to maintain product integrity.

Disclaimer

This product is sold strictly for scientific and laboratory research purposes only. Not for human consumption, medical, or therapeutic use. All buyers agree to use this compound in compliance with research regulations and handling standards.

Learn More

Explore additional insights in our IGF-1 LR3 Research Blog and view other compounds in our Peptide Shop.

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